Research

Nalin J. Mehta, MD

PAST/PRESENT RESEARCH INTERESTS
FDA coordinator, Expanded Phase III study: “Hydrokinetic Retinal Manipulation Using the Viscous Fluid Perfluorocarbon Vitreon® (Perfluorophenanthrene)”, New Orleans, LA
Principal Investigator, Vitreophage Vitreon® Study, Denver, CO
Principal Investigator, Escalon Silicone Oil Study, Denver, CO
Principal Investigator, Novartis VIP (Visudyne®) FDA Study (extended
Phase III), Denver, CO
Former President, Eye-Online, LLC
Former Partner/Officer, Home Health Telemed, Inc.
Former Partner/Officer, Western Telemedical Consultants, LLC
Participant: QUEST Registry of Visudyne Therapy for AMD: Lucentis and Triple Therapy Combinations ( Study RVT002); Sponsor: QLT Phototherapeutics.
Genentech: Dosing Patterns of Ranibizumab Chart Review
Principal Investigator, Collection of AMD and DME Data for the RTVue-100, Optovue, Inc.
Principal Investigator, Clinical Validation Study for iVue, Optovue Inc.
Principal Investigator, Age-Related Macular Degeneration (AMD) Beta Study Telemedicine
Assessment, Notal Vision, Ltd.
Principal Investigator, Intraoperative Spectral-Domain Optical Coherence Tomography (SD-OCT) in the Management of Retinal Disease
Sub-Investigator, Amgen Protocol 20080560, A Double-blind, Placebo-controlled Study to Evaluate New or Worsening Lens Opacifications in Subjects with Non-Metastatic Prostate Cancer Receiving Denosumab for Bone Loss due to Androgen-Deprivation Therapy

SELECTED PUBLICATIONS/PRESENTATIONS/ ABSTRACTS
Mehta NJ, Webb RM, Krohel GB, Smith RB: Clinical inefficacy of tobramycin and gentamicin sulfate in the treatment of ocular infections. Cornea 3:228, 1984/85.
Mehta NJ, Karmody AM, McKneaIly MF: Mediastinal veno-occlusive disease associated with herbal tea ingestion. New York State Journal of Medicine 86:11, 1986.
Mehta N, Majerovics A, Tanenbaum H: Laser energy transmission by fundus contact lenses. Poster Presentation, ARVO Annual Meeting, Sarasota, FL, 1986.
Wolf B, Mehta NJ: Naka-Rushton ERG parameters in the prediction of postvitrectomy visual acuity. International Society for Clinical Electrophysiology of Vision.
Mehta NJ, Zloty P, Mitsch M, Simmons ST: Optic nerve head analysis during artificially¬induced ocular hypertension: a pilot study. Presented at the Albany Ophthalmology Update, 1989.

Mehta NJ, Mitsch M, Zloty P, Cutro JM, Simmons ST, Kandell GL: Optic nerve head compliance during artificially-induced ocular hypertension. Presented at ARVO, 1990.
Simmons ST, Mehta NJ, Mitsch M: Comparison of optic disc image analysis with automated perimetry in the detection of glaucomatous progression. Presented at ARVO, 1990; also presented at the Albany Ophthalmology Update, 1990.
Simon JW, Simmons ST, Mehta NJ: Glaucoma following pediatric lensectomy-vitrectomy. Presented at the AAO meeting, 1990.
Simmons ST, Mehta NJ: Comparison of the image analysis change program with visual field/standard disc parameters. Presented at the AAO meeting, 1990.

Beer PM, Mehta NJ, Ludwig IH: Terson’s syndrome in the shaken baby: the importance of early vitrectomy. Presented at the Eighth Annual Vitreous Society Meeting, 1991.
Mehta NJ, Del Vecchio P, Kieval SJ: Photochemical effects of helium neon laser wavelengths upon retinal pigment epithelial cell metabolism. Presented at the Albany Ophthalmology Update, 1991.
Peyman GA, Alturki W, Mehta NJ, et al: Use of Vitreon®: a new perfluorocarbon liquid for complex retinal detachments. Presented at the Annual Scientific Meeting of the Saudi Ophthalmological Society, December 11-13, 1991.
Mehta NJ, Peyman GA, Alturki W A, et al: Multicenter evaluation of perfluoroperhydrophenanthrene in the management of complex vitreoretinal surgery. Presented at American Academy of Ophthalmology, 1992.
Sherwood MB, Simmons ST, Smith MF, Mehta NJ: Comparison of optic disk image analysis with automated perimetry in the detection of glaucomatous progression. Journal of the International Perimetric Society.
Simon JW, Mehta NJ, Simmons ST, Catalano RA, Lininger LL: Glaucoma after pediatric lensectomy/vitrectomy. Ophthalmology 98:670, 1991.
Peyman GA, Mehta NJ: Subretinal diathermy probe (letter). Am J Ophthalmol 114: 508-509, 1992.
Reilly KM, Chan L, Mehta NJ, Salluzzo RF. Systemic Toxicity from Ocular Homatropine. Academic Emergency Medicine, 1996; 3(9): 868-71.
SoheilianM, Peyman GA, Wafapoor H, Navarro GC, Thompson H, The Vitreon Study Group (incl. Mehta NJ). Surgical Management of traumatic retinal detachment with perfluorocarbon liquid. International Ophthalmology, 1996; 20(5): 241-249.
Peyman GA, Mehta NJ: Intravitreal infusion-aspiration instrument for silicon oil-perfluorocarbon liquid exchange (Letter). Retina. 1993; 13(2): 177.
Millsap CM, Peyman GA, Mehta NJ: A radiologic property of perfluoroperhydrophenanthrene. Ophthalmic Surg.

Mehta NJ, Alster Y: Cross-sensitivity analysis among a population of AMD patients monitored with the Preview PHP (Preferential Hyperacuity Perimeter). Poster Presentation; ARVO Annual Meeting, Ft. Lauderdale, FL, 2006
Mehta NJ: Monitoring for the conversion of dry to wet age-related macular degeneration. AMD Update. Ophthalmology Management. Issue 6 (Online), 2007.
Mehta NJ: Implications of early diagnosis in AMD (Age-Related Macular Degeneration); Lecture presented at Retina Symposium 2007 in Ft. Meyer, FL and W.A.V.E. (Western Association for Vitreoretinal Education) meeting, Maui, HI, 2007
Mehta NJ: Fourier-Domain OCT: Paradigm shift in the management of AMD; Lecture presented at W.A.V.E. meeting, Maui, HI, 2007
Mehta NJ: Implications of early diagnosis in AMD, and: Fourier-Domain OCT: Paradigm shift in the management of AMD. Lectures presented at OCT Symposium, Natramandir Eye Hospital, Mumbai, India, 2007
Mehta NJ: Implications of Early Diagnosis in AMD; Video Journal of Ophthalmology. 2008: XXIV(1).
Mehta NJ: Spectral (Fourier)- Domain OCT: A Paradigm Shift in Management of AMD. Video Journal of Ophthalmology. 2008: XXIV (4).
Mehta NJ: Applying SD OCT for Diagnosis and Management of Exudative AMD. Retina Today. 2009 (March): 76-77.
Mehta NJ: Evaluation of Choroidal Circulation using Collapsed C-Scan (en face) Imaging derived from Meta-Analysis of 3D Spectral-Domain (Fourier-Domain) OCT utilizing Automated Image Processing in Patients Undergoing Combination Therapy with Verteporfin (Visudyne®) and Ranibizumab (Lucentis®) for Exudative AMD. Poster Presentation; ARVO Annual Meeting, Ft. Lauderdale, FL, 2009.
Mehta NJ: Correlation Between Collapsed C-Scan (en face) Imaging using Spectral-Domain (Fourier-Domain) OCT and Hyperacuity Disturbance Mapping using the Foresee PHPTM (Preferential Hyperacuity Perimeter) in Patients with Geographic Atrophy Associated with AMD. Paper Presentation; ARVO/ISIE Annual Meeting, Ft. Lauderdale, FL, 2009.
Tolentino MJ, Mehta NJ, Harrell P, Espiritu MJ: Monitoring Anti-VEGF Therapy for Exudative Age-Related Macular Degeneration with the Preferential Hyperacuity Perimeter. Poster Presentation: ARVO Annual Meeting. Ft. Lauderdale, FL, 2009.
Mehta NJ: Differentiation of Sub-RPE Lesion Composition in AMD Using Automated Intensity Plotting of en face Images Derived from SD-OCT. Poster Presentation: AAO Annual Meeting, San Francisco, CA, 2009.
Mehta NJ, Quiroz-Mercado H, Pinero-Rodriguez AM, Jimenez-Sierra JM, Lopez-Ramos L: Evaluation of the Retinal Ganglion Cell Complex with Spectral Domain (Fourier-Domain) OCT in Patients Undergoing Anti-VEGF Therapy with Ranibizumab and Bevacizumab for Exudative Age-Related Macular Degeneration. Poster Presentation; ARVO Annual Meeting. Ft. Lauderdale, Fl, 2010.
Goldstein M, Loewenstein A, Lang Y, Katz H, Ferencz JR, Roth DB, Fine HF, Weston JM, Mehta NJ, Johnston R: Stability in Statistical Distribution of Test Scores Obtained by Intermediate AMD Patients Monitored with a Home Device Perimeter. Poster Presentation; ARVO Annual Meeting. Ft. Lauderdale, FL, 2010.
Mehta NJ: Intra-Operative Optical Coherence Tomography (OCT): From the Office to the Operating Room. Presented at Optovue, Inc. Annual Symposia ESRS 2010, Paris and AAO annual Meeting, Chicago. IL, 2010.
Mehta, NJ: Presenter: Optical Coherence Tomography Users Group Workshop: AAO annual Meeting, Chicago, IL, 2010.
Mehta NJ: In the Eye of the Beholder: The Psychology of Blindness and Visual Impairment. Lecture Presented at: Creativity and Madness, Big Island, HI, 2010.
Roth D, Fine H, Weston JM, Mehta N, Johnston R: Early Detection of Exudative Age-related Macular Degeneration with a Home-based Preferential Hyperacuity Perimeter. Paper Presentation: 34th Annual Macula Society Conference, Boca Raton, FL, 2011
Mehta NJ: Presenter: An Overview of Spectral (Fourier)-Domain Optical Coherence Tomography and its Role in AMD and other Retinal diseases. Presented at the Annual Convention of the New Mexico Optometric Society, Albuquerque, NM, 2011.
Mehta NJ, Stanescu D, Guo C: Quantitative Zonal Analysis of Macular Thickness Changes Pre- versus Post-Membranectomy using Intra-Operative Spectral-Domain Optical Coherence Tomography (SD-OCT). Poster Presentation: ARVO/ISIE Annual Meeting, Ft. Lauderdale, FL, 2011.
Mehta NJ, Stanescu D: A Novel Technique for Intraoperative Spectral Domain OCT During Vitreoretinal Surgery. Video Presentation: AAO Annual Meeting, Orlando, FL, 2010.
Baldivieso VG, Sinai MJ, Quiroz-Mercado H, Mehta NJ, et al: The effect of anti VEGF therapy for AMD on the Retinal Ganglion Cell Complex (GCC) measured with Fourier-Domain optical coherence tomography (FD-OCT). To be presented at the ARVO Annual Meeting, Ft. Lauderdale, FL, 2012.
Mehta NJ: Analysis of Choroidal Changes resulting from Intraoperative IOP Variations during Vitreoretinal Surgery using Automated Intensity Plotting of C-Scan (en face) Spectral-Domain Optical Coherence Tomography (SD-OCT) Images. To be presented at the ARVO Annual Meeting, Ft. Lauderdale, FL, 2012.